For the needs of the 11^th Territorial Military Command, in 1953 the 11^th Connections Company was constituted and on 1^st September 1956 it was named 6^th Signals Company.

Renamed 46^th Signals Company on 4^th November 1975, after the reorganization of the Army, on 1^st May 1976 it was changed into 46^th "Mongibello" Signals Battalion, at the dependencies of the Signals Command of the Sicily Military Region Command.

By decree of 12^th November 1976 the Battalion received the War Flag.

On 1^st September 1997 it was assigned to the Logistic Command – Southern Area of Naples; on 27^th October 1997, after the suppression of the Signals Command of Palermo, it became 46^th Signals Regiment, with the "Mongibello" Battalion at its dependencies, located in Palermo.

On 1^st October 1998 it passed at the dependencies of the C4-IEW Command of Anzio that in 2005 it was named Signals and Information Command of the Army (COTIE).

Since 1^st January 2001, after the dissolution of the 45^th Signals Regiment, the Regiment had also at its dependencies the "Vulture" Signals Battalion, located in Nocera Inferiore (SA), and the 25^th C4 Works Unit, located in San Giorgio a Cremano (NA).